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Bone Health Glossary · Bone biology

Epiphysis

Also called: epiphyses

Evidence
◆ Strong Clinical Evidence
Topic
Bone biology
Taught in
Pro Tier 2 · Lesson 8
In plain English

What it means

The epiphysis is the rounded end part of a long bone, found beyond the growth plate, that forms part of a joint.

Why it matters for your bones

The epiphysis forms the joint surfaces of your bones, so its health and the hormones that support it matter for lifelong joint and skeletal strength.

The epiphysis is the rounded end of a long bone, like the knobby ends of your femur (thigh bone) or humerus (upper arm bone). It sits beyond the growth plate and is covered with articular cartilage where it meets another bone to form a joint. In children and teens, the epiphysis is separated from the shaft by the growth plate, which closes once growth is complete.

Epiphyses matter in bone health discussions mostly because of how and when they fuse. Research on rare cases of men with impaired estrogen signaling has shown that these men can have unfused growth plates and low bone density even when testosterone levels are normal. This has helped researchers understand that estrogen, not just testosterone, plays an essential role in normal bone growth and growth plate closure in men, not only in women.

For adults, the epiphysis is no longer a 'growing' region, but it remains an important structural area, since it's where joints form and where fragility fractures (like hip fractures involving the femoral head, a type of epiphysis) often occur. Understanding its role helps explain why healthy sex hormone levels, in both men and women, support strong bone throughout life, not just during growth.

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✦ The aha

The epiphysis forms joint surfaces at the ends of long bones, shaping joint and skeletal strength for life.

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Where this leads

126 discoveries so far
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The epiphysis sits beyond the growth plate. Curious how that cartilage layer shaped your bone's final size before adulthood?

Growth plate
Take me there Standard Definition
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Where the Academy teaches it

This page is the short version. The lessons teach it in full, with the context around it and a quiz to lock it in.

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Related words

Growth plate
Standard Definition

A growth plate (epiphyseal plate, or physis) is a layer of cartilage near the ends of a child's or teen's long bones…

Diaphysis
Standard Definition

The diaphysis is the long middle shaft of a long bone, such as the femur or humerus, made mostly of dense cortical…

Metaphysis
Standard Definition

The metaphysis is the flared, wider section of a long bone located between its shaft and the rounded end near a…

Femoral head
Standard Definition

The femoral head is the rounded, ball-shaped top of the thighbone (femur) that fits into the hip socket to form the…

Femur
Strong Clinical Evidence

The femur, or thigh bone, is the longest and strongest bone in the body, stretching from the hip to the knee and…

Estrogen
Established Science

Estrogen is a hormone that protects bone by keeping bone-removing cells in check. Falling estrogen, especially at…

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