← Glossary / Risk & causes
Bone Health Glossary · Risk & causes

Atypical femoral fracture

Also called: AFF

Evidence
✓ Established Science
Topic
Risk & causes
Taught in
Tier 2 · Lesson 5
In plain English

What it means

An atypical femoral fracture is an uncommon break in the shaft of the thigh bone that looks and behaves differently from a typical fragility fracture.

Why it matters for your bones

Knowing this term helps you understand why your prescriber may discuss monitoring if you're on long-term bone medication.

An atypical femoral fracture is a rare break in the thigh bone that behaves differently from a typical fragility fracture. Instead of happening at the hip, it occurs along the shaft of the femur and tends to break in a straight, horizontal line rather than the jagged pattern seen in most bone fractures. This distinct pattern is part of why doctors classify it separately from a usual hip fracture.

These fractures fall into a category sometimes linked with medications that slow down bone remodeling, since the whole point of remodeling is to clear out old, worn bone and replace it with fresh bone. If that process is overly suppressed for a long stretch of time, bone in certain spots may not get the normal renewal it needs. Any questions or concerns about a specific medication and how it affects your bones should be discussed with your prescriber, who can weigh the full picture of your treatment.

If you're on a long-term bone medication, your prescriber may talk with you about monitoring and periodic reassessment as part of routine care. This isn't something to self-manage or guess about — it's a conversation to have with the doctor overseeing your treatment, who can consider your full history and the role your medication plays in your overall bone health.

Evidence

How sure is this?

The research behind this
Established Science

Graded Established Science: Supported by broad scientific consensus and decades of research. Read each study with its grade in mind. One study is a piece of the picture, not the whole of it.

2 peer-reviewed studies, free with an Academy login
Go deeper

Where the Academy teaches it

This page is the short version. The lessons teach it in full, with the context around it and a quiz to lock it in.

Keep going

Related words

Femoral neck
Established Science

The femoral neck is the angled part of bone joining your hip ball to your thigh bone shaft, and it's the most common…

Hip fracture
Established Science

A hip fracture is a break at the femoral neck, the narrow part of bone connecting the hip joint ball to the thigh…

Fragility fracture
Strong Clinical Evidence

A fragility fracture is a broken bone caused by a fall or bump that normally wouldn't break a healthy bone, often at…

Bisphosphonate
Strong Clinical Evidence

Bisphosphonates are osteoporosis medications — like alendronate, risedronate, and zoledronic acid — that slow down…

Bone remodeling
Established Science

Bone remodeling is the lifelong cycle where cells called osteoclasts remove old bone and osteoblasts build new bone…

Drug holiday
Strong Clinical Evidence

A drug holiday is a temporary, prescriber-guided pause from a bisphosphonate medication after several years of use,…

Education only, not medical advice. Decisions about tests, medications and treatment belong with your own doctor. OsteoStrong does not diagnose, treat or cure any disease.

Keep learning

More ways in