Sclerostin inhibitor
Also called: anti-sclerostin antibody, sclerostin blocker
What it means
A sclerostin inhibitor is a drug that blocks sclerostin, a protein that normally slows bone formation, helping the body build new bone while also reducing bone breakdown.
Understanding this class of medication can help you have an informed conversation with your doctor if you're at high risk of fracture.
A sclerostin inhibitor is a medication that blocks sclerostin, a protein made by bone cells called osteocytes. Normally, sclerostin acts like a brake on bone formation. By blocking it, these drugs release that brake, allowing new bone to be built while also reducing the breakdown of old bone at the same time.
Romosozumab (brand name Evenity) is the main sclerostin inhibitor used in osteoporosis care. It's given as an injection, usually for a limited course, often followed by another osteoporosis medication to help maintain the bone gained. It's typically considered for people at high fracture risk, including those with a prior fracture.
Like any prescription treatment, this medication carries specific considerations, including cardiovascular history, that your prescriber will review with you. Decisions about starting, stopping, or switching any osteoporosis medication should always be made with your doctor, based on your full health picture and bone density results.
Sclerostin inhibitors block a protein that normally slows bone formation, helping build new bone while reducing breakdown.
Where this leads
WordSclerostin inhibitors block sclerostin itself. Curious what this protein normally does and how mechanical strain affects its levels?
Where the Academy teaches it
This page is the short version. The lessons teach it in full, with the context around it and a quiz to lock it in.
Related words
Sclerostin is a protein made by bone cells called osteocytes that blocks new bone formation; less mechanical strain…
Romosozumab (brand name Evenity) is an anabolic osteoporosis medication given by injection that blocks sclerostin, a…
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Education only, not medical advice. Decisions about tests, medications and treatment belong with your own doctor. OsteoStrong does not diagnose, treat or cure any disease.
